Table 2 Calculated pIC50 values for inhibitors toward anti-CSF114(N-Glc) IgG antibodies.

From: Antibodies from multiple sclerosis patients preferentially recognize hyperglucosylated adhesin of non-typeable Haemophilus influenzae

 

Inhibitor

MS1

MS2

MS3

MS4

MS5

Mean value

95% C.I.*

1

I(Glc)

9.27 ± 0.07

8.88 ± 0.15

8.42 ± 0.28

9.34 ± 0.19

9.45 ± 0.16

9.07 ± 0.42

8.547–9.597

2

II(Glc)

8.59 ± 0.04

8.93 ± 0.18

9.94 ± 0.19

9.34 ± 0.10

9.77 ± 0.20

9.31 ± 0.56

8.614–10.01

3

III(Glc)

8.71 ± 0.11

8.28 ± 0.15

9.34 ± 0.38

9.25 ± 0.12

8.89 ± 0.08

8.89 ± 0.43

8.361–9.427

4

IV(Glc)

10.14 ± 0.03

8.26 ± 0.08

not tested

not tested

8.56 ± 0.27

8.99 ± 1.01

6.478–11.50

5

V(Glc)

7.59 ± 0.16

7.21 ± 0.07

6.69 ± 0.14

6.89 ± 0.05

7.56 ± 0.27

7.19 ± 0.40

6.692–7.684

6

I

<6.0

<6.0

<6.0

<6.0

<6.0

n.a.

n.a.

7

II

<6.0

<6.0

<6.0

<6.0

<6.0

n.a.

n.a.

8

III

<6.0

6.80 ± 0.23

<6.0

6.17 ± 1.06

6.44 ± 0.73

6.47 ± 0.32

5.685–7.255

9

IV

<6.0

<6.0

not tested

not tested

<6.0

n.a.

n.a.

10

V

<6.0

<6.0

6.41 ± 0.44

<6.0

<6.0

n.a.

n.a.

11

CSF114(N-Glc)

7.25 ± 0.07

7.17 ± 0.09

8.05 ± 0.26

7.69 ± 0.14

7.66 ± 0.53

7.56 ± 0.36

7.118–8.010

  1. Values are reported as calculated pIC50 ± the standard error (SEM) of the N-glucosylated adhesin antigens (I(Glc)-V(Glc)) and the corresponding non-glucosylated analogs (I-V) used as inhibitors of anti-CSF114(N-Glc) antibodies in 5 representative MS sera.
  2. *95% confidence interval (C.I.).
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