Table 3 Toxicity in the E. coli-asparaginase and PEG-asparaginase groups.

From: Use of PEG-asparaginase in newly diagnosed adults with standard-risk acute lymphoblastic leukemia compared with E. coli-asparaginase: a retrospective single-center study

 

Grades 1/2 n (%)

P

Grades 3/4 n (%)

P

E. coli- asparaginase

PEG- asparaginase

E. coli- asparaginase

PEG- asparaginase

Pancreatitis

0 (0.0)

0 (0.0)

—

4 (9.8)

4 (5.8)

0.715

Transaminitis

11 (21.6)

13 (30.8)

0.647

7 (15.7)

8 (13.5)

0.780

Hyperbilirubinemia

13 (15.7)

15 (19.2)

0.519

8 (21.6)

13 (13.5)

0.812

Hypoalbuminemia

11 (25.5)

14 (28.8)

0.821

8 (19.6)

9 (21.2)

0.604

Hyperglycemia

6 (15.7)

11 (21.2)

0.791

8 (15.7)

13 (9.6)

0.812

Hypertriglyceridemia

7 (17.6)

12 (23.1)

0.802

5 (13.7)

10 (15.4)

0.586

Hypofibrinogenemia

11 (25.5)

18 (21.2)

0.830

8 (13.7)

10 (23.1)

0.798

DVT

1 (2.0)

4 (2.0)

0.648

3 (5.9)

2 (1.9)

0.399

  1. Abbreviations: E. coli-asparaginase, Escherichia coli asparaginase; PEG-asparaginase, polyethylene glycol-conjugated asparaginase; DVT, deep vein thrombosis.
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