Figure 4: Train the Brain intervention increases Cerebral Blood Flow (CBF) in Medial Temporal Lobe (MTL) regions. | Scientific Reports

Figure 4: Train the Brain intervention increases Cerebral Blood Flow (CBF) in Medial Temporal Lobe (MTL) regions.

From: Randomized trial on the effects of a combined physical/cognitive training in aged MCI subjects: the Train the Brain study

Figure 4

Voxel-wise paired t-test analysis between T0 and T7 for both the MCI-training and –no training groups (a) Increase of CBF in the MCI-training group (n = 48) at T7 with respect to T0 (p threshold 0.001). (b) No significant change of CBF between T0 and T7 was found in the MCI-no training group (n = 22). Lower line/row). Change of CBF during the 7 months intervention in (c) the hippocampus and (d) the parahippocampal regions Mean change from baseline is presented (positive differences correspond to higher CBF at T7 than T0. Error bars are s.e.m. In the parahippocampal region, two way mixed model ANOVA, time x treatment, revealed a significant time x treatment interaction (p < 0.05) with MCI-training subjects showing a significant improvement (*) and MCI-no training subjects showing a not significant decrease.

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