Figure 6 | Scientific Reports

Figure 6

From: Blocking triggering receptor expressed on myeloid cells-1 attenuates lipopolysaccharide-induced acute lung injury via inhibiting NLRP3 inflammasome activation

Figure 6

LR12 suppressed LPS-induced expression of the NLRP3 inflammasome components.

Mice received saline, LR12 (5 mg/kg) and LRS (5 mg/kg) intravenous injection, respectively. Two hours later, mice were treated with either saline or LPS (5 mg/kg, i.t.) for 6 h. The mRNA expression of ASC (a), NLRP3 (b) and pro-caspase-1 (c) were determined by Real-time PCR. (n = 4–7). Data are expressed as the mean ± SEM. **P < 0.01 vs Control group, ##P < 0.01 vs LRS+LPS group.

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