Figure 7 | Scientific Reports

Figure 7

From: Blocking triggering receptor expressed on myeloid cells-1 attenuates lipopolysaccharide-induced acute lung injury via inhibiting NLRP3 inflammasome activation

Figure 7

LR12 inhibited LPS-induced NLRP3 inflammasome activation.

Mice received saline, LR12 (5 mg/kg) and LRS (5 mg/kg) intravenous injection, respectively. Two hours later, mice were treated with either saline or LPS (5 mg/kg, i.t.) for 6 h. The protein level of NLRP3 (a and b), Caspase-1 p10 (a and c) in the lung were assessed by Western-blot analysis. β-actin was used as an internal control. The immunofluorescent assay was used to detect expression of NLRP3 protein (d) in situ (n = 4–7, Bar = 100 μm). Data are expressed as the mean ± SEM. *P < 0.05 and **P < 0.01 vs Control group, #P < 0.05 and ##P < 0.01 vs LRS+LPS group.

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