Table 2 Relationship between pri-let-7e rs8111742, pri-miR-365b rs121224, pri-miR-4795 rs1002765 and risk of atrophic gastritis and gastric cancer.
Control group (%) | Atrophic gastritis group (%) | Atrophic gastritis group vs. control group | Control group (%) | Cancer group (%) | Cancer group vs. control group | |||
|---|---|---|---|---|---|---|---|---|
P | OR(95%CI) | P | OR(95%CI) | |||||
n = 862 | n = 862 | n = 729 | n = 724 | |||||
pri-let7e rs8111742 | ||||||||
GG | 459(53.2) | 458(53.1) | 1.00 | 389(53.4) | 375(51.8) | 1.00 | ||
GA | 341(39.6) | 343(39.8) | 0.921 | 1.01(0.82–1.25) | 285(39.1) | 291(40.2) | 0.690 | 1.05(0.84–1.31) |
AA | 62(7.2) | 61(7.1) | 0.987 | 1.00(0.67–1.48) | 55(7.5) | 58(8.0) | 0.795 | 1.06(0.70–1.59) |
AA + GA vs. GG | 0.927 | 1.01(0.83–1.23) | 0.667 | 1.05(0.85–1.30) | ||||
AA vs. GA + GG | 0.984 | 1.00(0.68–1.47) | 0.854 | 1.04(0.70–1.54) | ||||
A vs. G | 0.929 | 1.01(0.86–1.18) | 0.658 | 1.04(0.88–1.23) | ||||
HWPa | 0.185 | 0.778 | 0.78 | 0.882 | ||||
pri-miR-365b rs121224 | ||||||||
CC | 270(31.3) | 272(31.6) | 1.00 | 229(31.4) | 221(30.5) | 1.00 | ||
CG | 428(49.7) | 413(47.9) | 0.436 | 0.91(0.73–1.15) | 362(49.7) | 376(51.9) | 0.630 | 1.06(0.83–1.35) |
GG | 164(19.0) | 177(20.5) | 0.604 | 1.08(0.81–1.43) | 138(18.9) | 127(17.5) | 0.806 | 0.96(0.70–1.32) |
CG + GG vs. CC | 0.695 | 0.96(0.77–1.19) | 0.773 | 1.03(0.82–1.30) | ||||
GG vs. CG + CC | 0.334 | 1.13(0.88–1.45) | 0.593 | 0.93(0.71–1.22) | ||||
G vs. C | 0.730 | 1.03(0.89–1.18) | 0.963 | 1.00(0.86–1.16) | ||||
HWPa | 0.8 | 0.3 | 0.811 | 0.129 | ||||
pri-miR4795 rs1002765 | ||||||||
GG | 307(35.6) | 304(35.3) | 1.00 | 262(35.9) | 272(37.6) | 1.00 | ||
GA | 420(48.7) | 416(48.3) | 0.766 | 1.03(0.83–1.29) | 357(49.0) | 349(48.2) | 0.619 | 0.94(0.75–1.19) |
AA | 135(15.7) | 142(16.5) | 0.654 | 1.07(0.79–1.45) | 110(15.1) | 103(14.2) | 0.703 | 0.94(0.67–1.30) |
AA + GA vs. GG | 0.694 | 1.04(0.85–1.28) | 0.590 | 0.94(0.76–1.17) | ||||
AA vs. GA + GG | 0.721 | 1.05(0.80–1.38) | 0.774 | 0.96(0.71–1.29) | ||||
A vs. G | 0.638 | 1.04(0.90–1.20) | 0.609 | 0.96(0.82–1.12) | ||||
HWPa | 0.662 | 0.988 | 0.518 | 0.597 | ||||
