Table 5 Stratified analysis of pri-let-7e rs8111742, pri-miR-365b rs121224, pri-miR-4795 rs1002765 and risk of intestinal type and diffuse type gastric cancer.
Variables | Genotype | Control group | Intestinal type gastric cancer | Diffuse type gastric cancer | Intestinal type gastric cancer vs. control group | Diffuse type gastric cancer vs. control group | ||
|---|---|---|---|---|---|---|---|---|
P | OR(95%CI) | P | OR(95%CI) | |||||
pri-let7e rs8111742 | ||||||||
H. pylori a | ||||||||
Negative | GG | 278(52.7) | 75(58.1) | 95(52.8) | 1.00 | 1.00 | ||
GA | 206(39.0) | 49(38.0) | 69(38.3) | 0.573 | 0.89(0.60–1.33) | 0.816 | 0.96(0.67–1.37) | |
AA | 44(8.3) | 5(3.9) | 16(8.9) | 0.118 | 0.46(0.18–1.21) | 0.621 | 1.17(0.63–2.16) | |
GA + AA vs. GG | 0.321 | 0.82(0.56–1.21) | 0.966 | 0.99(0.71–1.39) | ||||
AA vs. GA + GG | 0.136 | 0.48(0.19–1.26) | 0.587 | 1.18(0.65–2.15) | ||||
Positive | GG | 111(55.2) | 70(49.3) | 90(47.9) | 1.00 | 1.00 | ||
GA | 79(39.3) | 58(40.8) | 77(41.0) | 0.454 | 1.19(0.75–1.89) | 0.434 | 1.18(0.78–1.77) | |
AA | 11(5.5) | 14(9.9) | 21(11.2) | 0.229 | 1.65(0.73–3.75) | 0.057 | 2.01(0.98–4.12) | |
GA + AA vs. GG | 0.313 | 1.25(0.81–1.94) | 0.177 | 1.30(0.89–1.91) | ||||
AA vs. GA + GG | 0.339 | 1.48(0.66–3.32) | 0.059 | 1.95(0.97–3.92) | ||||
Smoking statusb | ||||||||
Smokers | GG | 104(52.3) | 39(53.4) | 28(42.4) | 1.00 | 1.00 | ||
GA | 78(39.2) | 29(39.7) | 32(48.5) | 0.972 | 1.01(0.56–1.84) | 0.113 | 1.65(0.89–3.06) | |
AA | 17(8.5) | 5(6.8) | 6(9.1) | 0.666 | 0.77(0.24–2.51) | 0.409 | 1.61(0.52–4.95) | |
GA + AA vs. GG | 0.914 | 0.97(0.54–1.74) | 0.085 | 1.69(0.93–3.08) | ||||
AA vs. GA + GG | 0.612 | 0.74(0.23–2.39) | 0.628 | 1.30(0.45–3.80) | ||||
Non-smokers | GG | 159(52.8) | 35(53.) | 49(50.5) | 1.00 | 1.00 | ||
GA | 122(40.5) | 27(40.9) | 39(40.2) | 0.813 | 0.93(0.53–1.66) | 0.636 | 0.89(0.54–1.45) | |
AA | 20(6.6) | 4(6.1) | 9(9.3) | 0.911 | 0.94(0.29–2.98) | 0.484 | 1.37(0.57–3.26) | |
GA + AA vs. GG | 0.795 | 0.93(0.53–1.62) | 0.812 | 0.95(0.59–1.51) | ||||
AA vs. GA + GG | 0.903 | 0.93(0.30–2.89) | 0.382 | 1.45(0.63–3.35) | ||||
Drinking statusb | ||||||||
Drinkers | GG | 73(50.0) | 20(50.0) | 25(42.4) | 1.00 | 1.00 | ||
GA | 63(43.2) | 18(45.0) | 28(47.5) | 0.638 | 1.21(0.56–2.62) | 0.254 | 1.46(0.76–2.81) | |
AA | 10(6.8) | 2(5.0) | 6(10.2) | 0.565 | 0.59(0.10–3.53) | 0.354 | 1.71(0.55–5.35) | |
GA + AA vs. GG | 0.743 | 1.14(0.53–2.42) | 0.185 | 1.53(0.82–2.88) | ||||
AA vs. GA + GG | 0.557 | 0.59(0.10–3.40) | 0.531 | 1.42(0.47–4.25) | ||||
Non-drinkers | GG | 187(53.0) | 35(53.0) | 49(49.0) | 1.00 | 1.00 | ||
GA | 138(39.1) | 26(39.4) | 42(42.0) | 0.689 | 0.89(0.49–1.59) | 0.838 | 0.95(0.59–1.54) | |
AA | 28(7.9) | 5(7.6) | 9(9.0) | 0.877 | 0.92(0.32–2.66) | 0.486 | 1.35(0.58–3.14) | |
GA + AA vs. GG | 0.654 | 0.88(0.50–1.54) | 0.973 | 1.01(0.64–1.60) | ||||
AA vs. GA + GG | 0.941 | 0.96(0.34–2.75) | 0.399 | 1.42(0.63–3.20) | ||||
pri-miR-365b rs121224 | ||||||||
H. pylori a | ||||||||
Negative | CC | 171(32.4) | 36(27.9) | 51(28.3) | 1.00 | 1.00 | ||
CG | 258(48.9) | 62(48.1) | 96(53.3) | 0.621 | 1.12(0.71–1.77) | 0.250 | 1.26(0.85–1.85) | |
GG | 99(18.8) | 31(24.0) | 33(18.3) | 0.144 | 0.50(0.87–2.57)_ | 0.699 | 1.10(0.67–1.82) | |
CG + GG vs. CC | 0.348 | 1.23(0.80–1.88) | 0.314 | 1.21(0.84–1.75) | ||||
GG vs. CG + CC | 0.147 | 1.41(0.89–2.23) | 0.837 | 0.96(0.62–1.47) | ||||
Positive | CC | 58(28.9) | 44(31.0) | 60(31.9) | 1.00 | 1.00 | ||
CG | 104(51.7) | 70(49.3) | 103(54.8) | 0.663 | 0.90(0.54–1.47) | 0.969 | 0.99(0.64–1.53) | |
GG | 39(19.4) | 28(19.7) | 25(13.3) | 0.779 | 0.91(0.48–1.75) | 0.157 | 0.65(0.36–1.18) | |
CG + GG vs. CC | 0.665 | 0.90(0.56–1.45) | 0.617 | 0.90(0.59–1.36) | ||||
GG vs. CG + CC | 0.996 | 1.00(0.58–1.73) | 0.121 | 0.66(0.39–1.12) | ||||
Smoking statusb | ||||||||
Smokers | CC | 74(37.2) | 20(27.4) | 19(28.8) | 1.00 | 1.00 | ||
CG | 95(47.7) | 38(52.1) | 39(259.1) | 0.411 | 1.32(0.68–2.56) | 0.340 | 1.39(0.71–2.70) | |
GG | 30(15.1) | 15(20.5) | 8(12.1) | 0.475 | 1.33(0.61–2.87) | 0.948 | 0.97(0.37–2.55) | |
CG + GG vs. CC | 0.328 | 1.37(0.73–2.58) | 0.424 | 1.30(0.68–2.46) | ||||
GG vs. CG + CC | 0.512 | 1.28(0.61–2.69) | 0.625 | 0.81(0.34–1.92) | ||||
Non-smokers | CC | 88(29.2) | 19(28.8) | 28(28.9) | 1.00 | 1.00 | ||
CG | 150(49.8) | 30(45.5) | 56(57.7) | 0.956 | 1.02(0.53–1.95) | |||
GG | 63(20.9) | 17(25.8) | 13(13.4) | 0.361 | 1.50(0.63–3.59) | 0.317 | 0.68(0.32–1.44) | |
CG + GG vs. CC | 0.755 | 1.10(0.60–2.03) | 0.742 | 1.09(0.65–1.82) | ||||
GG vs. CG + CC | 0.430 | 1.29(0.68–2.45) | 0.109 | 0.58(0.30–1.13) | ||||
Drinking statusb | ||||||||
Drinkers | CC | 45(30.8) | 8(20.0) | 21(35.6) | 1.00 | 1.00 | ||
CG | 81(55.0) | 21(52.5) | 30(50.8) | 0.288 | 1.69(0.64–4.46) | 0.706 | 0.88(0.44–1.74) | |
GG | 20(13.7) | 11(27.5) | 8(13.6) | 0.029 | 3.76(1.15–12.34) | 0.756 | 0.85(0.32–2.31) | |
CG + GG vs. CC | 0.131 | 2.02(0.81–5.05) | 0.688 | 0.87(0.45–1.69) | ||||
GG vs. CG + CC | 0.045 | 2.52(1.02–6.23) | 0.833 | 0.91(0.37–2.23) | ||||
Non-drinkers | CC | 117(33.1) | 20(30.3) | 26(26.0) | 1.00 | 1.00 | ||
CG | 164(45.6) | 30(45.5) | 62(62.0) | 0.978 | 0.99(0.52–1.88) | 0.104 | 1.56(0.91–2.66) | |
GG | 72(20.4) | 16(24.2) | 12(12.0) | 0.861 | 1.07(0.49–2.35) | 0.407 | 0.72(0.34–1.56) | |
CG + GG vs. CC | 0.933 | 1.03(0.56–1.87) | 0.302 | 1.31(0.78–2.19) | ||||
GG vs. CG + CC | 0.781 | 1.10(0.57–2.13) | 0.073 | 0.54(0.27–1.06) | ||||
pri-miR4795 rs1002765 | ||||||||
H. pylori a | ||||||||
Negative | GG | 197(37.3) | 49(38.0) | 66(36.7) | 1.00 | 1.00 | ||
GA | 259(49.1) | 58(45.0) | 86(47.8) | 0.898 | 0.97(0.64–1.49) | 0.882 | 1.03(0.71–1.48) | |
AA | 72(13.6) | 22(17.1) | 28(15.6) | 0.422 | 1.27(0.71–2.24) | 0.712 | 1.10(0.66–1.85) | |
GA + AA vs. GG | 0.850 | 1.04(0.70–1.55) | 0.809 | 1.04(0.74–1.48) | ||||
AA vs. GA + GG | 0.319 | 1.31(0.77–2.20) | 0.685 | 1.10(0.69–1.76) | ||||
Positive | GG | 65(32.3) | 52(36.6) | 76(40.4) | 1.00 | 1.00 | ||
GA | 98(48.8) | 66(46.5) | 95(50.5) | 0.337 | 0.79(0.49–1.28) | 0.295 | 0.80(0.53–1.22) | |
AA | 38(18.9) | 24(16.9) | 17(9.0) | 0.504 | 0.80(0.41–1.56) | 0.005 | 0.39(0.20–0.75) | |
GA + AA vs. GG | 0.317 | 0.79(0.50–1.25) | 0.062 | 0.68(0.46–1.02) | ||||
AA vs. GA + GG | 0.771 | 0.92(0.52–1.63) | 0.005 | 0.43(0.24–0.78) | ||||
Smoking statusb | ||||||||
Smokers | GG | 73(36.7) | 29(39.7) | 28(42.4) | 1.00 | 1.00 | ||
GA | 102(51.3) | 32(43.8) | 34(51.5) | 0.492 | 0.80(0.43–1.51) | 0.454 | 0.78(0.41–1.48) | |
AA | 24(12.1) | 12(16.4) | 4(6.1) | 0.986 | 0.99(0.39–2.51) | 0.057 | 0.29(0.08–1.04) | |
GA + AA vs. GG | 0.648 | 0.87(0.48–1.59) | 0.258 | 0.70(0.38–1.30) | ||||
AA vs. GA + GG | 0.785 | 1.12(0.49–2.58) | 0.153 | 0.43(0.14–1.37) | ||||
Non-smokers | GG | 98(32.6) | 23(34.8) | 32(33.0) | 1.00 | 1.00 | ||
GA | 156(51.8) | 34(51.5) | 52(53.6) | 0.924 | 1.03(0.56–1.89) | 0.692 | 1.11(0.66–1.87) | |
AA | 47(15.6) | 9(13.6) | 13(13.4) | 0.58 | 0.78(0.33–1.86) | 0.438 | 0.75(0.35–1.57) | |
GA + AA vs. GG | 0.889 | 0.96(0.54–1.71) | 0.941 | 1.02(0.62–1.67) | ||||
AA vs. GA + GG | 0.496 | 0.76(0.35–1.66) | 0.308 | 0.71(0.36–1.38) | ||||
Drinking statusb | ||||||||
Drinkers | GG | 47(32.2) | 9(22.5) | 28(47.5) | 1.00 | 1.00 | ||
GA | 75(51.4) | 21(52.5) | 26(44.1) | 0.428 | 1.45(0.58–3.65) | 0.070 | 0.53(0.27–1.05) | |
AA | 24(16.4) | 10(25.0) | 5(8.5) | 0.187 | 2.19(0.68–7.03) | 0.069 | 0.35(0.11–1.09) | |
GA + AA vs. GG | 0.270 | 1.65(0.68–3.99) | 0.032 | 0.49(0.25–0.94) | ||||
AA vs. GA + GG | 0.274 | 1.68(0.66–4.26) | 0.232 | 0.53(0.19–1.51) | ||||
Non-drinkers | GG | 124(35.1) | 24(36.4) | 30(30.0) | 1.00 | 1.00 | ||
GA | 182(51.6) | 32(48.5) | 58(58.0) | 0.931 | 0.97(0.53–1.79) | 0.308 | 1.31(0.78–2.20) | |
AA | 47(13.3) | 10(15.2) | 12(12.0) | 0.857 | 0.92(0.39–3.19) | 0.661 | 0.84(0.39–1.81) | |
GA + AA vs. GG | 0.900 | 0.96(0.54–1.72) | 0.472 | 1.20(0.73–1.97) | ||||
AA vs. GA + GG | 0.844 | 0.93(0.43–1.99) | 0.314 | 0.70(0.35–1.40) | ||||
