Figure 2 | Scientific Reports

Figure 2

From: Interaction of cytokeratin 19 head domain and HER2 in the cytoplasm leads to activation of HER2-Erk pathway

Figure 2

Immunofluorescent and immunohistochemical staining in lung cancer cell lines and primary tumors.

(A) Expression levels of HER2 and KRT19 in HEK293T, HBEC5KT, A549 (HER2-wild type), NCI-H1781 (HER2-mutant), and NCI-H2170 (HER2-amplified) are shown. (B) NCI-H2170 cells. (C) PC9 cells. (D) HER2 knock downed NCI-H2170 with siRNA. (E) HER2-positive and KRT19-positive primary lung cancer. (E) HER2-negative and KRT19-positive primary lung cancer. Location of KRT19 was different according to the expression of HER2 in both cell lines and clinical samples. Full-length blots are presented in Supplementary Fig. S9.

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