Table 3 Total bone mineral density (BMD) score at L-spine and FRAX^® score for major osteoporotic and hip fractures.

Variable	Time	CAB group (N = 234)		GnRH group (N = 70)		Difference 95% C.I.	Between groups p-value¤
Total bone marrow density (BMD) score at L-spine
Changes in total BMD score		n	Mean ± SD	n	Mean ± SD
	Baseline	223	1.16 ± 0.25	63	1.15 ± 0.22		0.8636^§
	12 Month	184	1.13 ± 0.26	55	1.09 ± 0.19
		176	−0.04 ± 0.14	48	−0.05 ± 0.06	0.01 (−0.03, 0.06)	0.4887^§
	Within group p-value	0.0009^§§		<0.0001^§§
Rate of BMD change		176	−2.61 ± 13.11	48	−4.37 ± 5.04	1.77(−2.04, 5.57)	0.1518^§
Rate of BMD change	Within group p−value	0.0090^§§		<0.0001^§§
FRAX ^® score of major osteoporotic and hip fractures
Major osteoporotic fracture (%)	Baseline	234	5.08 ± 3.14	70	5.35 ± 2.75		0.5194^§
	12 month	186	4.96 ± 2.84	55	5.85 ± 3.48
	change	186	−0.23 ± 2.79	55	0.20 ± 2.74		0.3189^§
	Within group p-value	0.2635^§§		0.5973^§§
Hip fracture (%)	Baseline	234	1.50 ± 1.54	70	1.87 ± 1.78		0.0943^§
	12 month	186	1.69 ± 1.76	55	2.41 ± 2.53
	change	186	0.20 ± 1.16	55	0.36 ± 1.97		0.5531^§
	Within group p-value	0.0231^§§		0.1798^§§§

Change = score at 12 month − score at baseline Rate of BMD change = (BMD score at 12 month − BMD score at baseline)/BMD score at baseline ×100 Difference = CAB group − GnRH group ^¤ p-value of difference between groups (CAB group − GnRH group): ^§Two sample t-test ^§§Paired t-test.

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