Figure 5
From: Impaired Hepatic Adaptation to Chronic Cholestasis induced by Primary Sclerosing Cholangitis
Hepatic expressions of adaptive response genes and relevant nuclear receptors.
(a) In the liver tissue, FGF19 mRNA and protein levels were significantly increased in PSC patients compared to in control tissue. (b) FGFR4 protein expression was enhanced in the liver tissue of patients with PSC compared to that of controls. (c) FXR protein levels were considerably increased in patients with PSC compared to controls (d), which was accompanied by enhanced SHP protein expression. mRNA expression levels were normalized relative to glyceraldehyde 3-phosphate dehydrogenase (GAPDH). Changes in protein levels were determined using densitometry analyses after normalization to Ī±/Ī²-tubulin or actin as a loading control. Gene expression levels are presented as fold-change relative to control.
