Figure 4: Immunohistochemical assessment of human TPP-1 expressed by I-124AAVrh.10CLN2 using the Iodogen method.

Images are sequential coronal sections 5 μm apart and obtained on sacrifice, 4.5 weeks after vector administration. TPP-1 staining is observed in the cortex and striatum with halo-like patterns of cell bodies (left) as compared to background staining of the neighboring section using an irrelevant IgG (right).