Figure 2: nsPEFs and everolimus synergistically inhibited melanoma cell growth in vitro. | Scientific Reports

Figure 2: nsPEFs and everolimus synergistically inhibited melanoma cell growth in vitro.

From: Nanosecond Pulsed Electric Fields Enhance the Anti-tumour Effects of the mTOR Inhibitor Everolimus against Melanoma

Figure 2

(a) and (b) Were effects of everolimus on the proliferation of melanoma cells in vitro. A375 and A875 cells were treated with elevated concentrations of everolimus for 24 h, 48 h, and 72 h. Cell viabilities were determined by CellTiter-Glo analysis. (c) and (d) Cells were first treated with nsPEFs, followed by incubation with everolimus for 48 h; or treated with everolimus for 48 h prior to nsPEF treatment. Synergism quotients (SQ) are shown for both treatment orders. Mean ± SD values of triplicate samples were determined. *P < 0.05 compared to control, #P < 0.05 compared to everolimus single agent treatment.

Back to article page