Figure 3 | Scientific Reports

Figure 3

From: Differential identity of Filopodia and Tunneling Nanotubes revealed by the opposite functions of actin regulatory complexes

Figure 3

CDC42, IRSp53, and VASP act as a network to negatively regulate the number of TNT-connected cells.

CAD cells were transiently co-transfected as indicated under the graph. Cells were fixed 14 hrs post-transfection, labeled with fluorescent WGA in order to detect TNTs and observed by confocal microscopy. The ratio of TNT-forming cotransfected cells/number of cotransfected cells was evaluated. Data represent the mean (±SEM), normalized to control cells arbitrarily set at 100%, of at least 4 independent experiments. *P < 0.05; **P < 0.01; ***P < 0.001; ns = not significant.

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