Figure 2: Sequence and solution structure of JNJ63955918. | Scientific Reports

Figure 2: Sequence and solution structure of JNJ63955918.

From: Insensitivity to pain induced by a potent selective closed-state Nav1.7 inhibitor

Figure 2

(A) The sequence of JNJ63955918 and ProTX-II highlighting cysteine residues with disulfide connectivity, asterisks indicate residue differences. (B) Backbone chemical shifts (HN, Hα) of ProTx-II and JNJ63955918 (see Supplementary Table 4 for chemical shifts). (C) Backbone superimposition of the ensemble (20 structures) of lowest energy conformers of JNJ63955918 (pdb accession number 5TCZ, BMRB accession number 30181). Disulfide CYS pairings are shown as blue, red, and green bonds.).

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