Figure 3: Concentration dependent inhibition of human Nav1 channels by JNJ63955918 measured in QPatch.
From: Insensitivity to pain induced by a potent selective closed-state Nav1.7 inhibitor
Control (●); 1 nM (
); 3 nM (
); 10 nM (
); 30 nM (
); 100 nM (
); 300 nM (
); 1 μM (
); 3 μM (
) JNJ63955918. Positive control agents (TTX or lidocaine) were added at 30 min.
