Figure 4: Representative traces to illustrate inhibition of human Nav1 channels by JNJ63955918 measured by manual patch clamp. | Scientific Reports

Figure 4: Representative traces to illustrate inhibition of human Nav1 channels by JNJ63955918 measured by manual patch clamp.

From: Insensitivity to pain induced by a potent selective closed-state Nav1.7 inhibitor

Figure 4

Black traces are control, red traces are after addition of JNJ63955918 at either 1 μM (A,C,D,F), 3 μM (B) or 10 μM (E). (G–J) show representative TTX-sensitive (G), mixed (H), TTX-resistant (I) and persistent (J) sodium currents recorded from small and medium diameter rat DRG neurons. Black lines are control responses, red lines are currents in the presence of 300 nM JNJ63955918 and blue lines are currents recorded in the presence of 1 μM TTX.

Back to article page