Figure 5: Human and rat Nav1.x pharmacology of ProTX-II and JNJ63955918.
From: Insensitivity to pain induced by a potent selective closed-state Nav1.7 inhibitor
Concentration-dependent inhibition of Nav1.7 (red), Nav1.1 (blue), Nav1.2 (green), Nav1.3 (purple), Nav1.4 (black), Nav1.5 (pink) and Nav1.6 (orange) by ProTX-II (A) or JNJ63955918 (B–D). Data shown in panels A and B were generated using automated patch clamp. Data shown in (C and D) were generated by manual patch clamp. Data were generated using either human (A–C) or rat (D) sodium channel isoforms.
