Figure 6: Closed-state block of hNav1.7 by JNJ63855918.
From: Insensitivity to pain induced by a potent selective closed-state Nav1.7 inhibitor
(A) Average current-voltage relationship for hNav1.7 before (black) or after (red) addition of 300 nM JNJ63955918 (B) Average steady-state inactivation curves for hNav1.7 before (black) or after (red) addition of 300 nM JNJ63955918 (C) Normalized current-voltage curves measured in time-matched control cells (black) and cells exposed to 300 nM JNJ63955918 (red) (D) Normalized activation curves derived from the data shown in (C). (E) Normalized steady-state inactivation curves measured in time-matched control cells (black) and cells exposed to 300 nM JNJ63955918 (red).
