Table 2 Summary of in-vivo pharmacology of JNJ63955918.
From: Insensitivity to pain induced by a potent selective closed-state Nav1.7 inhibitor
Model | Compound | Route | pED50 (−log g) |
|---|---|---|---|
Hotplate | JNJ63955918 | i.t. bolus | 6.1 ± 0.06 |
Tail Flick | JNJ63955918 | i.t. bolus | 6.5 ± 0.06 |
Formalin (phase II) | JNJ63955918 | i.t. bolus | 6.3 ± 0.15 |
Formalin (phase II) | ProTX-II | i.t. bolus | >5.7 |
Formalin (phase II) | ziconotide | i.t. bolus | 7.1 ± 0.18 |
Formalin (phase II) | morphine | i.t. bolus | 5.4 ± 0.22 |
