Figure 4: Stability and relationships of defining lymphocyte populations. | Scientific Reports

Figure 4: Stability and relationships of defining lymphocyte populations.

From: Common Variable Immunodeficiency patients with a phenotypic profile of immunosenescence present with thrombocytopenia

Figure 4

CVID-AcT patients’ samples contain the same proportion of the defining populations (naïve, intermediate CD28+CD27− CD4+ T-cells, CD21lo B-cells) when measured more than 3 years apart, which is in contrast to the dynamic compartment of terminal effector CD8+ T-cells. The line connecting the two time points is shown to visualize the trends (A). Investigation of the mutual relationship of the relevant populations shows orchestrated changes in the patients’ immunophenotypes (B).

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