Figure 5: Clinical signs of CVID-AcT patients are correlated with immunosenescence (activation of immune system and loss of naive T-cells). | Scientific Reports

Figure 5: Clinical signs of CVID-AcT patients are correlated with immunosenescence (activation of immune system and loss of naive T-cells).

From: Common Variable Immunodeficiency patients with a phenotypic profile of immunosenescence present with thrombocytopenia

Figure 5

The phenotype of CVID-AcT exhibited signs of immunosenescence in agreement with the higher average age of patients in this cluster. The phenotypic hallmarks of the CVID-AcT patients correlated significantly with age (compared to the T-cell hallmarks both in CVID patients and healthy donors). Additionally, the T-cell phenotype seems to change with age at the same rate in the CVID patients and healthy donors (with no significant difference in the slope), but the CVID patients begin with a decreased number of T-cells compared to the healthy controls (A). The phenotypic hallmarks of CVID-AcT correlated significantly (after adjustment for multiple testing) with the severity of their clinical signs (B).

Back to article page