Figure 2: NMR screening of compounds to NUPR1. | Scientific Reports

Figure 2: NMR screening of compounds to NUPR1.

From: Identification of a Drug Targeting an Intrinsically Disordered Protein Involved in Pancreatic Adenocarcinoma

Figure 2

(A) 2D 1H-15N HSQC spectra of isolated NUPR1 (red) at 100 μM; NUPR1 and Compound-9 (black) (100:400 μM); and NUPR1 and Compound-15 (blue) (100:400 μM). (B) Rows from the 1H-15N HSQC spectra corresponding at the 15N chemical shift of Thr68 for isolated NUPR1 (red) and NUPR1 with Compound-15 added (black). The signal at 8.00 ppm appearing in both rows corresponds to the carrier position. Experiments were acquired at 25 °C and pH 4.5.

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