Table 3 Association between combined risk genotypes of MDM2rs2279744 and MDM2rs937283 and recurrence risk in 1008 patients with SCCOP.
Combined MDM2 genotypes | No. of recurrences/no. of patients | 5-year recurrence rate, % | Log-rank P value | aHR * (95% CI) |
|---|---|---|---|---|
Low-risk group †| 23/379 | 6 | <0.0001 | 1.0 |
Medium-risk group | 83/490 | 17 |  | 2.7 (1.7–4.2) |
High-risk group | 75/139 | 57 |  | 10.9 (6.8–17.4) |
Trend test | Â | Â | <0.001 | Â |
Combined MDM2 genotypes | No. of risk genotypes (no. of recurrences/no. of patients) | Genotypes of MDM2 polymorphisms | aHR * (95% CI) | |
| Â | Â | rs2279744 | rs937283 | Â |
1 | Low (9/205) | GG †| GG †| 1.0 |
2 | Low (5/71) | GG | AG | 1.9 (0.3–3.2) |
3 | Medium (19/192) | GG | AA | 3.4 (1.1–5.8) |
4 | Low (4/67) | GT | GG | 1.4 (0.4–4.2) |
5 | Low (5/36) | GT | AG | 2.6 (0.6–5.3) |
6 | Medium (28/99) | GT | AA | 11.2 (6.5–20.1) |
7 | Medium (4/67) | TT | GG | 1.9 (1.0–3.7) |
8 | Medium (32/132) | TT | AG | 7.1 (3.7–13.6) |
9 | High (75/139) | TT | AA | 26.8 (10.3–48.7) |
