Table 4 Association between MDM2rs2279744 and MDM2rs937283 genotypes and recurrence risk in 324 patients with human papillomavirus–positive SCCOP.

From: Modifying effect of mouse double minute-2 promoter variants on risk of recurrence for patients with squamous cell carcinoma of oropharynx

Genotypes

No. of recurrences/no. of patients

5-year recurrence rate, %

Log-rank P value

aHR * (95% CI)

MDM2rs2279744

  

<0.0001

 

 GT/GG †

10/178

7

 

1.0

 TT

35/146

26

 

4.4 (2.2–8.9)

MDM2rs937283

 AG/GG †

10/268

4

<0.0001

1.0

 AA

35/56

70

 

23.7 (11.5–48.8)

  1. aHR, adjusted hazard ratio; CI, confidence interval.
  2. *Adjusted for age, sex, ethnicity, smoking status, alcohol use status, disease stage, comorbidity, and treatment.
  3. †Reference group.
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