Table 5 Association between combined risk genotypes of MDM2rs2279744 and MDM2rs937283 and recurrence risk in 324 patients with human papillomavirus–positive SCCOP.

From: Modifying effect of mouse double minute-2 promoter variants on risk of recurrence for patients with squamous cell carcinoma of oropharynx

Combined MDM2 genotypes

No. of recurrences/no. of patients

5-year recurrence rate, %

Log-rank P value

aHR * (95% CI)

Low-risk group †

2/163

2

<0.0001

1.0

Medium-risk group

16/120

16

 

10.6 (2.4–46.2)

High-risk group

27/41

74

 

72.7 (17.1–308.6)

Trend test

  

<0.001

 
  1. aHR, adjusted hazard ratio; CI, confidence interval.
  2. *Adjusted for age, sex, ethnicity, smoking status, alcohol use status, disease stage, comorbidity, and treatment.
  3. †Reference group.
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