Figure 4: Gain of H3K4me3 at promoter may lead to increased expression and/or inducibility, whereas loss of H3K4me3 may lead to loss of expression and/or inducibility.
From: Rapid Recall Ability of Memory T cells is Encoded in their Epigenome
On the left tag density heatmaps show the level of H3K4me3 within 5 kb around TSS for genes that gained (a) or lost (b) H3K4me3 islands at the promoter in the transition from naïve T cells (Naïve) to effector memory T cells (TEM). On the right heatmaps show level of expression for the corresponding genes in resting cells (R) and cells activated for the period shown.
