Figure 1
Improved control of Listeria monocytogenes during primary infection but impaired clearance upon rechallenge in CD4-Cre A20fl/fl mice.
(a) Experimental design: CD4-Cre A20fl/fl and A20fl/fl control mice were infected with Lm and spleens were analyzed at the indicated time points. Reinfection was performed 50 days after the primary infection. (b) CFU in spleen was determined at day 3, 7 and 14 after infection with Lm WT. (c) CFU in spleen after Lm OVA infection was determined at day 7 and 14 p.i. (d) CFU in spleen of Lm WT infected mice at day 50 and 3 days after reinfection at day 53. (e) CFU in spleen of Lm OVA infected mice at day 50 and 3 days after reinfection at day 53. Data are compiled of 3 independent experiments with 3-5 animals per group and experiment. Error bars indicate + SEM. Non-parametric Mann Whitney test, with *p < 0.05, **p < 0.01.
