Figure 6 | Scientific Reports

Figure 6

From: Acetyl-11-Keto-β-Boswellic Acid Attenuates Prooxidant and Profibrotic Mechanisms Involving Transforming Growth Factor-β1, and Improves Vascular Remodeling in Spontaneously Hypertensive Rats

Figure 6

AKBA inhibited TGF-β1/Smad3 pathway in vitro.

TGF-β1/Smad3 and several proteins in cell extracts involved in this pathway were assessed by western blot in vitro. AKBA effectively decreased (a) TGF-β1, (b) Smad3 and P-Smad3, (c) Smad7 levels. The conclusion is that AKBA can notably inhibit TGF-β1/Smad3 pathway, but have no modification effect on (d) α-SMA and (e) collagen-1 expression within 24 h treatment in vitro. The data are represented as mean ± SD (n = 5). #P < 0.05, ###P < 0.001 vs. control group; *P < 0.05, **P < 0.01, ***P < 0.001 vs. model group.

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