Figure 2: Gene expression analyses in the colons of patients with Behçet’s disease and inflammatory bowel disease and the inflamed colons of mice. | Scientific Reports

Figure 2: Gene expression analyses in the colons of patients with Behçet’s disease and inflammatory bowel disease and the inflamed colons of mice.

From: Identification of genetic susceptibility loci for intestinal Behçet’s disease

Figure 2

(a,b) Immunohistochemistry of NAALADL2 (a) and YIPF7 (b). Right panels show expression scores according to diseases and SNP genotypes (NAALADL2, rs3914501; YIPF7: rs6838327). Pink and blue show NAALADL2 and the nucleus, respectively. The genotype is indicated in parentheses. (c,d) mRNA levels in inflamed colon tissues. (c) Transcript levels of NAALADL2 from control, TNBS-, and DSS-treated mouse colon tissues. Data represent mean ± SEM. (d) Transcript levels of IL17 and IL10 in colon tissues from control and intestinal BD patients (controls, n = 7; intestinal BD, n = 8). mRNA levels were quantified by qRT-PCR. *P < 0.05 vs. CTL, **P < 0.005 vs. CTL or Sham. Data represent mean ± SD. BD, intestinal Behçet’s diseases; CTL, control; IBD, inflammatory bowel disease; TNBS, 2,4 6-trinitrobenzenesulfonic acid; DSS, dextran sulfate sodium.

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