Table 3 Association results of comparison between healthy controls and patients with intestinal Behçet’s disease.
From: Identification of genetic susceptibility loci for intestinal Behçet’s disease
SNP | MA | Locus | Nearby genes † | GWAS | Replicated | Combined | ||||
|---|---|---|---|---|---|---|---|---|---|---|
P Model | aP value Model | MAF: Intestinal BD | aP value Model | OR (95% CI) | MAF: Intestinal BD | MAF: Healthy control | ||||
rs1554286 * | G | Chr. 1: 206944233 | IL10 | 7.6 × 10−1 Codominant | 4.0 × 10−3 Codominant | 0.237 | 7.6 × 10−3 Codominant | 0.717 (0.562–0.915) | 0.252 | 0.318 |
rs1800871 * | C | Chr. 1: 206946634 | IL10 | — | 5.8 × 10−3 Codominant | 0.232 | 9.1 × 10−3 Codominant | 0.722 (0.564–0.922) | 0.245 | 0.309 |
rs1518111 * | C | Chr. 1: 206944645 | IL10 | — | 5.4 × 10−3 Allelic | 0.234 | 7.6 × 10−3 Allelic | 0.717 (0.562–0.916) | 0.247 | 0.313 |
rs7556581 | A | Chr. 1: 116386105 | NHLH2 | 7.1 × 10−5 Recessive | 3.7 × 10−1 Recessive | 0.379 | 1.1 × 10−2 Recessive | 1.731 (1.131–2.649) | 0.402 | 0.350 |
rs284148 | T | Chr.1: 92277843 | TGFBR3 | 8.8 × 10−5 Dominant | 3.5 × 10−1 Dominant | 0.420 | 1.2 × 10−2 Dominant | 0.667 (0.486–0.916) | 0.381 | 0.425 |
rs16830589 | C | Chr.3: 159365432 | SCHIP1 | 2.5 × 10−5 Dominant | 2.0 × 10−1 Dominant | 0.204 | 4.7 × 10−3 Dominant | 1.579 (1.15–2.167) | 0.231 | 0.182 |
rs16830581 | G | Chr.3: 159362915 | SCHIP1 | 1.5 × 10−5 Dominant | 3.4 × 10−1 Dominant | 0.194 | 7.6 × 10−3 Dominant | 1.544 (1.122–2.126) | 0.225 | 0.178 |
rs3914501 | G | Chr. 3: 174564668 | NAALADL2 | 5.7 × 10−5 Recessive | 1.6 × 10−2 Recessive | 0.505 | 3.8 × 10−4Recessive | 1.914 (1.338–2.738) | 0.537 | 0.459 |
rs16848171 | C | Chr. 3: 174564668 | NAALADL2 | 4.0 × 10−5 Recessive | 9.3 × 10−2 Recessive | 0.227 | 7.0 × 10−3 Recessive | 2.462 (1.279–4.739) | 0.248 | 0.219 |
rs6838327 | A | Chr. 4: 44626846 | YIPF7 | 4.6 × 10−3 Recessive | 1.2 × 10−1 Recessive | 0.482 | 6.4 × 10−3 Recessive | 1.654 (1.152–2.376) | 0.519 | 0.468 |
rs32019 | C | Chr. 5: 66702373 | CD180 | – | 4.4 × 10−2 Codominant | 0.551 | 4.0 × 10−3 Codominant | 1.265 (1.023–1.563) | 0.548 | 0.487 |
rs10259514 | G | Chr. 7: 36829705 | ELMO1 | 4.3 × 10−5 Allelic | 1.4 × 10−1 Allelic | 0.277 | 4.8 × 10−3 Allelic | 0.706 (0.554–0.899) | 0.249 | 0.320 |
rs10441723 | C | Chr. 9: 34082144 | DCAF12 | 4.2 × 10−5 Codominant | 3.5 × 10−1 Codominant | 0.295 | 9.5 × 10−3 Codominant | 0.725 (0.568–0.924) | 0.256 | 0.321 |
rs10758242 | A | Chr. 9: 34146776 | DCAF12 | 2.6 × 10−5 Allelic | 2.1 × 10−1 Allelic | 0.283 | 2.8 × 10−3 Allelic | 0.689 (0.54–0.88) | 0.245 | 0.320 |
rs12624809 | C | Chr.20: 8822431 | PLCB1 | 8.5 × 10−6 Dominant | 6.5 × 10−1 Dominant | 0.653 | 3.0 × 10−2 Dominant | 1.403 (1.034–1.905) | 0.696 | 0.671 |
rs6086632 | C | Chr.20: 8822931 | PLCB1 | 7.8 × 10−6 Dominant | 7.9 × 10−1 Dominant | 0.649 | 3.7 × 10−2 Dominant | 1.385 (1.019–1.880) | 0.694 | 0.671 |
rs6086633 | T | Chr.20: 8823064 | PLCB1 | 6.8 × 10−6 Dominant | 7.4 × 10−1 Dominant | 0.652 | 3.7 × 10−2 Dominant | 1.383 (1.019–1.876) | 0.695 | 0.671 |
rs6039302 | T | Chr.20: 8831137 | PLCB1 | 1.1 × 10−5 Dominant | 7.1 × 10−1 Dominant | 0658 | 3.3 × 10−2 Dominant | 1.397 (1.028–1.898) | 0.701 | 0.675 |
rs6086653 | G | Chr.20: 8838343 | PLCB1 | 3.5 × 10−5 Dominant | 6.2 × 10−1 Dominant | 0.668 | 4.3 × 10−2 Dominant | 1.371 (1.010–1.862) | 0.707 | 0.688 |
