Figure 1: SSAO inhibitors attenuate mechanical hyperalgesia and inflammatory signs in the K/BxN serum-transfer arthritis model. | Scientific Reports

Figure 1: SSAO inhibitors attenuate mechanical hyperalgesia and inflammatory signs in the K/BxN serum-transfer arthritis model.

From: Analgesic and Anti-Inflammatory Effects of the Novel Semicarbazide-Sensitive Amine-Oxidase Inhibitor SzV-1287 in Chronic Arthritis Models of the Mouse

Figure 1

Alterations of the (A) mechanonociceptive threshold, (B) paw volume, (C) semiquantitative clinical score, and (D) time spent on the grid in arthritic mice treated with the vehicle, SzV-1287 or LJP-1207 (20 mg/kg/day i.p. every day during the 13-day experimental period) as compared to the BxN serum-injected non-arthritic controls. Data are shown as means ± S.E.M. of n = 8–9 mice/group, *p < 0.05, **p < 0.01, ***p < 0.001 (vs. vehicle-treated arthritic mice), #p < 0.05, ###p < 0.001 (vs. vehicle-treated control mice); two-way ANOVA followed by Bonferroni’s multiple comparison test.

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