Figure 3: SSAO inhibitors decrease CFA-induced chronic mechanical hyperalgesia and oedema. | Scientific Reports

Figure 3: SSAO inhibitors decrease CFA-induced chronic mechanical hyperalgesia and oedema.

From: Analgesic and Anti-Inflammatory Effects of the Novel Semicarbazide-Sensitive Amine-Oxidase Inhibitor SzV-1287 in Chronic Arthritis Models of the Mouse

Figure 3

Changes of the (A) mechanonociceptive threshold and (B) paw volume in response to CFA injection into the paw and the tail root. The effects of SzV-1287 and LJP-1207 (20 mg/kg/day i.p. every day during the 21-day experimental period) were compared to the vehicle-treated control group. Data are shown as means ± S.E.M. of n = 6–8 mice/group, *p < 0.05, **p < 0.01, ***p < 0.001 (vs. respective limb of vehicle-treated mice); two-way ANOVA followed by Bonferroni’s multiple comparison test.

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