Figure 6: SzV-1287 decreases histopathological alterations in the tibiotarsal joint in response to CFA injection. | Scientific Reports

Figure 6: SzV-1287 decreases histopathological alterations in the tibiotarsal joint in response to CFA injection.

From: Analgesic and Anti-Inflammatory Effects of the Novel Semicarbazide-Sensitive Amine-Oxidase Inhibitor SzV-1287 in Chronic Arthritis Models of the Mouse

Figure 6

Representative slides stained with hematoxylin-eosin of (A–C) the tibiotarsal joint of vehicle-, SzV-1287- and LJP-1207-treated (20 mg/kg/day i.p. every day during the 21-day experimental period) arthritic mice. (A: 40x, B (Vehicle, LJP-1207): 400x, B (SzV-1287): 200x, C (Vehicle, LJP-1207): 200x, C (SzV-1287): 100x magnification, Ti = Tibia bone, Ta = Tarsal bone, S = Synovium). (D) Semiquantitative histopathological scoring on the basis of inflammatory cell infiltration, synovial hyperplasia, cartilage destruction and bone erosion. Box plots shows medians of composite scores of n = 4–8 mice/group, ***p < 0.001 (vs. ipsilateral ankle joint of vehicle-treated mice), ###p < 0.001 (vs. respective contralateral ankle joint); one-way ANOVA followed by Bonferroni’s multiple comparison test.

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