Figure 6: Tamoxifen-induced PHF14 knockout in adult mouse kidneys. | Scientific Reports

Figure 6: Tamoxifen-induced PHF14 knockout in adult mouse kidneys.

From: PHF14: an innate inhibitor against the progression of renal fibrosis following folic acid-induced kidney injury

Figure 6

(A) Quantitative PCR of phf14 in the control group (phf14 flox/flox Cre−) and the phf14-knockout group (phf14 flox/flox Cre+) before (day 0) and after five consecutive days (day 6) of an intraperitoneal tamoxifen injection. *P < 0.05, compared with controls at day 6; #P < 0.05, compared with mice in the knockout group at day 0. (B) Western blot results showing the decrease of PHF14 protein expression in phf14 flox/flox Cre+ mice after tamoxifen administration, compared with control mice. (C) Semiquantitative analysis of PHF14 protein abundance in kidneys of phf14 flox/flox Cre+ mice and phf14 flox/flox Cre− mice (n = 5).

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