Figure 1: The OPRM1 A118G polymorphism is associated with diverse functional expressions of the pain modulatory system during menstruation in primary dysmenorrheic women and controls. | Scientific Reports

Figure 1: The OPRM1 A118G polymorphism is associated with diverse functional expressions of the pain modulatory system during menstruation in primary dysmenorrheic women and controls.

From: The OPRM1 A118G polymorphism modulates the descending pain modulatory system for individual pain experience in young women with primary dysmenorrhea

Figure 1

Regions showed significant FC with the PAG of between-genotype (a–c) and between-group (d) comparisons. Each region’s coordinates are listed in Table 4. (a) Overall, G allele carriers exhibited decreased PAG-ACC/mPFC and -dlPFC FC compared with AA homozygotes. (b) In healthy subjects, G allele carriers exhibited decreased PAG-ACC, -dlPFC and -middle temporal gyrus FC compared with AA homozygotes. (c) In PDM subjects, G allele carriers exhibited decreased PAG-ACC/mPFC, -orbitofrontal cortex and -superior parietal lobule FC compared with AA homozygotes. (d) Only among G allele carriers did PDM subjects exhibit increased PAG-supplementary motor area FC compared with the controls. Results in (a,b,d) were thresholded at the uncorrected voxel level p = 0.005, followed by the FWE-corrected cluster level p = 0.05; results in c were thresholded at the uncorrected voxel level p = 0.005, voxels >60. The color bar denotes the t-scores. Figures are displayed according to neurological convention (left = left). FC, functional connectivity; PAG, periaqueductal gray; ACC, anterior cingulate cortex; dlPFC, dorsolateral prefrontal cortex; mPFC, medial prefrontal cortex; PDM, primary dysmenorrhea.

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