Table 4 Peak MNI coordinates of the regions exhibiting significant resting-state FC with the PAG for the between-genotype and between-group differences.

Contrast	Phase	Region	BA	Cluster	t Score	Peak coordinate
Contrast	Phase	Region	BA	Cluster	t Score	x	y	z
G allele carriers overall < AA homozygotes overall	Menstruation	mPFC	9	1227	3.92	14	44	32
		dlPFC	8	—	3.02	48	26	44
		ACC	32	968	3.67	−14	36	18
G allele carrier controls < AA homozygous controls	Menstruation	dlPFC	8	452	3.84	38	36	46
		Temporal	21	588	3.58	60	−36	−12
		ACC	32	387	3.19	−18	42	10
G allele carrier PDMs < AA homozygous PDMs	Menstruation	Occipital	19	151	4.04	−38	−80	14
		SPL	7	104	3.53	26	−76	54
		Orbitofrontal	11	63	3.36	14	30	−22
		ACC	24	165	3.11	14	−4	42
		mPFC	9	60	2.95	18	40	32
G allele carrier PDMs < AA homozygous PDMs	Peri-ovulatory phase	Cerebellum	—	443	4.02	−26	−54	−56
G allele carrier PDMs > G allele carrier controls	Menstruation	SMA	6	566	4.51	2	−18	56

Peak coordinates refer to the Montreal Neurological Institute space. Significance was thresholded at the uncorrected voxel level p = 0.005, followed by the FWE-corrected cluster level p = 0.05, except the between-genotype comparison for PDM subjects. The contrast of G allele carrier PDMs < AA homozygous PDMs was thresholded at the uncorrected voxel level p = 0.005, voxels > 60. ACC, anterior cingulate cortex; BA, Brodmann area; dlPFC, dorsolateral prefrontal cortex; mPFC, medial prefrontal cortex; SMA, supplementary motor area; SPL, superior parietal lobule.

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