Table 2 Parabens and paraben metabolites in HaCaT cells with and without UV light treatment.

From: A derivatization-enhanced detection strategy in mass spectrometry: analysis of 4-hydroxybenzoates and their metabolites after keratinocytes are exposed to UV radiation

Compound a

UV Radiation

Control

UVC

UVB

UVA

MP treatment

 Dansyl-MP

V

V

V

V

 Dansyl-OH-MP

V

V

V

V

 Dansyl-4-HBA

V

V

V

V

 Dansyl-3,4-DHBA

—

V

—

—

EP treatment

 Dansyl-EP

V

V

V

V

 Dansyl-OH-EP

V

V

V

V

 Dansyl-4-HBA

V

V

V

V

 Dansyl-3,4-DHBA

—

V

—

—

PP treatment

 Dansyl-PP

V

V

V

V

 Dansyl-OH-PP

V

V

V

V

 Dansyl-4-HBA

V

V

V

V

 Dansyl-3,4-DHBA

—

—

—

—

BP treatment

 Dansyl-BP

V

V

V

V

 Dansyl-OH-BP

V

V

V

V

 Dansyl-4-HBA

V

V

V

V

 Dansyl-3,4-DHBA

—

—

—

—

  1. aMP,EP, PP and BP are methyl, ethyl, propyl and butyl parabens; 4-HBA, 4-hydroxybenzoic acid; 3,4-DHBA, 3,4-dihydroxybenzoic acid. Dansyl is the 5-(dimethylamino)naphthalene-1-sulfonyl group. The symbols “V” and “—” mean detectable and undetectable, respectively.
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