Figure 3: Effect of treatment with estradiol on spermatogenesis.
From: Effects of Elevated β-Estradiol Levels on the Functional Morphology of the Testis - New Insights
(A) Estradiol treatment results in only spermatogonia being present in the seminiferous tubules (→ spermatogonia, H&E). (B) Seminiferous tubule from a patient w/o estradiol treatment demonstrating all of the cells of spermatogenesis (→ spermatogonia; ➤ spermatocytes; ➛ round spermatids; ➼ elongated spermatids, H&E). (C) Two patients receiving estradiol only or estradiol and antiandrogens for 6 years, showed single spermatozoa in the seminiferous tubules (circle, H&E). (D) Immunofluorescent localization of MAGEA4 in estradiol treated patients demonstrated that nearly all cells in the seminiferous tubules are spermatogonia.
