Table 1 Type of hormonal treatment, dosage and duration of treatment.

From: Effects of Elevated β-Estradiol Levels on the Functional Morphology of the Testis - New Insights

Patient number

Age

Treatment Regimen

1

26

Estradiol gel (Sisare®). 2 mg/day for 21 months. GnRH analog: goserelin acetate (Zoladex®). 10.8 mg implant 3 times a month as start up, then every 3 months. 21 months in total.

2

49

Estradiol gel (Gynokadin Dosiergel®). 4 mg/day as start up, then 2 mg/day. 6 years in total. Antiandrogen: cyproterone acetate (Androcur®). 10 mg/day for 6 years.

3

47

Oral Estradiol (Estrofem®). 2 mg/day for 20 months. Antiandrogen: cyproterone acetate (Androcur®). 10 mg/day for 20 months.

4

52

Estradiol gel (Sisare®). 2 mg/day for 24 months. Progestin: Dydrogesterone (Duphaston®). 10 mg/day for 24 months.

5

40

Estradiol gel (Gynokadin Dosiergel®). 2 mg/day for 24 months. Weaned 9 days before surgery. Antiandrogen: cyproterone acetate (Androcur®). 10 mg/day for 24 months. Progesterone gel (Progestogel®) 2 mg/day for 24 months. Weaned 9 days before surgery.

6

26

Estradiol gel (Gynokadin Dosiergel®) 2 mg/day for 24 months.

7

48

Estradiol gel (Sisare®). 2 mg/day for 36 months. Antiandrogen: cyproterone acetate (Androcur®). 10 mg/day for 36 months.

8

41

Estradiol gel (Gynokadin Dosiergel®). 2 mg/day for 18 months. Antiandrogen: cyproterone acetate (Androcur®). 10 mg/day for 18 months.

9

46

Estradiol gel (Sisare®). 4 mg/day for 36 months. Antiandrogen: cyproterone acetate (Androcur®). 15 mg/day for 36 months.