Figure 1: The mast cell clock mediates temporal regulation of plasma histamine levels in mice.
From: Regulation of plasma histamine levels by the mast cell clock and its modulation by stress
(A) Comparisons of steady-state plasma histamine levels at the indicated time points between wild-type and mast cell–deficient mice (left panel), and between wild-type mice and ClockΔ19/Δ19 mice (right panel). (n = 5) (One-way ANOVA with Bonferroni’s test). (B) Plasma histamine levels at ZT4 or ZT16 in the steady states in mast cell–deficient mice reconstituted with subcutaneous injections of wild-type BMMCs or ClockΔ19/Δ19 BMMCs. (n = 5–7) (One-way ANOVA with Bonferroni’s test). (C) Kinetics of net histamine release from wild-type and ClockΔ19/Δ19 BMMCs during the indicated culture periods, with or without serum shock. (n = 4) (One-way ANOVA). (D) Kinetics of net histamine release from fetal skin–derived mast cells (FSMCs) during the indicated culture periods. (n = 4) (One-way ANOVA) Similar results (A–D) were obtained at least from 2 independent experiments. The values represent means ± SD, *p < 0.05, **p < 0.01.
