Figure 5: Plasma histamine levels are correlated with the degree of compound 48/80–induced plasma extravasation.
From: Regulation of plasma histamine levels by the mast cell clock and its modulation by stress
(A) Compound 48/80–induced plasma extravasation at ZT4 and ZT16 in wild-type and ClockΔ19/Δ19 mice. (n = 6). (B) Compound 48/80–induced plasma extravasation at ZT4 and ZT16 in vehicle- or D22-treated wild-type mice as described in Fig. 2. (n = 5). (C) Compound 48/80–induced plasma extravasation at AM 10:00 and PM 10:00 in mice housed under LD10/10 and LD12/12 cycles as described in Fig. 3. (n = 5–8). (D) Compound 48/80–induced plasma extravasation at ZT4 and ZT16 in control and sub-acute restraint-stressed mice as described in Fig. 4. (n = 5–10) Representative pictures and quantitative analysis of the data are shown. The values represent means ± SD. *p < 0.05 (Unpaired student’s t-test) Similar results (A–D) were obtained at least from 2 independent experiments.
