Table 5 Changes in the Glycopattern of Mitochondria Glycoproteins in Cerebral Cortex of MCAO rat model.

From: Comparison of the glycopattern alterations of mitochondrial proteins in cerebral cortex between rat Alzheimer’s disease and the cerebral ischemia model

Lectins

Specificity Glycans

Ratio

M16/MC

M48/MC

ECA

Galβ-1,4GlcNAc (type II), Galβ1-3GlcNAc (type I)

1.99

2.20

WFA

terminating in GalNAcα/β1-3/6 Gal

2.54

2.17

PTL-I

GalNAc, GalNAcα-1,3 Gal, GalNAcα-1,3Galβ-1,3/4Glc

2.66

1.74

LCA

α-D-Man, Fucα-1,6GlcNAc, α-D-Glc

2.24

2.37

VVA

terminal GalNAc, GalNAcα-Ser/Thr(Tn), GalNAcα1-3 Gal

1.93

1.75

GNA

High-Mannose, Manα1-3Man

1.94

2.67

PHA-E + L

Bisecting GlcNAc, bi-antennary N-glycans, tri- and tetra-antennary complex-type N-glycan

1.68

1.94

DBA

αGalNAc, Tn antigen, GalNAcα1-3((Fucα1-2))Gal (blood group A antigen)

1.39

1.58

PTL-II

Gal, blood group H, T-antigen

1.35

1.84

NPA

High-Mannose, Manα1-6Man

1.43

1.69

SNA

Sia2-6Gal/GalNAc

1.47

1.60

SJA

Terminal in GalNAc and Gal

0.40

0.33

GLS-I

αGalNAc, αGal, anti-A and B

0.58

0.77

STL

trimers and tetramers of GlcNAc, core (GlcNAc) of N-glycan, oligosaccharidecontaining GlcNAc and MurNAc

0.46

0.54

ConA

High-Mannose, Manα1-6(Manα1-3)Man, αMannose, αGlc

0.45

0.45

BPL

Galβ1-3GalNAc, Terminal GalNAc

0.55

0.52

PHA-E

Bisecting GlcNAc, biantennary complex-type N-glycan with outer Gal

0.74

0.64

LEL

(GlcNAc)n, high mannose-type N-glycans

0.70

0.53

  1. Changes were identified by lectin microarray analysis based on data of 18 lectins giving significant differences (Fold change ≥1.5 or ≤0.67). The NFIs of each lectin from this three groups were compared based upon fold-changes.
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