Figure 4: The impact of an endothelial niche on fatty acid and glycerophospholipids metabolism in ovarian and colon cancer cell lines.

(A) Alteration patterns of PUFA’s (n-6 and n-3), representing all cancer cell lines (OVCAR3, SKOV3, HCT15 and HCT116) are shown as box plots. (B) Alteration patterns of glycerophospholipids, representing all cancer cell lines (OVCAR3, SKOV3, HCT15 and HCT116) are shown as box plots. Red reflects significant increase observed in all cancer cell lines at given time point in comparison with control (time point 0, highlighted in yellow). Gray indicates no significant changes observed for all cancer cell lines. The striped pattern reflects alterations identified as significant over the entire experiment. The significance level was p ≤ 3.49 × 10−04 (p ≤ 0.05/143).