Table 1 List of metabolites showing significant alterations in cancer cells induced by endothelial cells at the different time points independent of cell line and cancer origin.
Metabolite | Pathway | Time | 0–6 h | 0–18 h | 0–24 h | 0–48 h |
|---|---|---|---|---|---|---|
5-methylthioadenosine (MTA) | Amino acid | 1.2 × 10−6↑ | 3.6 × 10−6↑ | |||
Glutathione reduced (GSH) | 3.4 × 10−6↑ | 3.4 × 10−6↑ | ||||
N-acetylglutamate | 1.4 × 10−06↑ | |||||
Lactose | Carbohydrates | 2.9 × 10−6↑ | ||||
N-acetylneuraminate | 2.3 × 10−5↑ | |||||
Isobar: UDP-acetylglucosamine, UDP-Acetylgalactosamine | 5.3 × 10−8↓ | 6.7 × 10−5↓ | 1.6 × 10−4↓ | 1.1 × 10−4↓ | ||
UDP-glucuronate | 9.3 × 10−12↓ | 8.8 × 10−7↓ | ||||
Pantothenate | Co&V | 8.6 × 10−5↑ | ||||
Arachidonate (20:4n6) | Lipid | 1.2 × 10−4↑ | 1.1 × 10−5↑ | 7.4 × 10−5↑ | 1.9 × 10−4↑ | |
Choline | 6.5 × 10−5↑ | 1.8 × 10−4↑ | 1.8 × 10−4↑ | |||
Cytidine 5′-diphosphocholine | 1.3 × 10−5↑ | 2.0 × 10−5↑ | 5.0 × 10−6↑ | 3.1 × 10−4↑ | ||
Dihomo-linolenate (20:3n3) | 1.8 × 10−4↑ | 1.3 × 10−5↑ | ||||
Docosapentaenoate (DPA 22:5n3) | 1.1 × 10−4↑ | 3.4 × 10−4↑ | 1.2 × 10−6↑ | 3.2 × 10−6↑ | 3.2 × 10−6↑ | |
Eicosapentaenoate (EPA 20:5n3) | 2.0 × 10−6↑ | 1.0 × 10−4↑ | 3.3 × 10−8↑ | 1.3 × 10−6↑ | 5.6 × 10−8↑ | |
Glycerophosphorylcholine (GPC) | 2.4 × 10−4↑ | |||||
Docosahexaenoate (DHA 22:6n3) | 7.9 × 10−5↑ | 1.3 × 10−4↑ | 3.2 × 10−4↑ | |||
Linoleate (18:2n6) | 1.7 × 10−4↑ | 2.3 × 10−4↑ | ||||
Cytidine 5′-monophosphate (5′-CMP) | Nucleotide | 2.0 × 10−4↑ | ||||
Gamma-glutamylglutamate | Polypeptide | 1.4 × 10−4↑ | 2.3 × 10−6↑ | |||
X – 14577 | Unknown | 9.8 × 10−6↑ | 1.9 × 10−4↑ | |||
X – 11583 | 1.5 × 10−4↑ |
