Figure 6: Inhibition of PV interneurons increases synchronous calcium signals in cortical neurons in vivo.
From: Simultaneous high-speed imaging and optogenetic inhibition in the intact mouse brain
(a) Confocal image showing GCaMP6s (green) in layer II/III neurons and tdTomato (red) expression in PV interneurons. (b,b1) GCaMP6s-expressing neurons. Cells are numbered in (b1). Depth: 190 μm. (c) Simultaneous scanless imaging and single-photon stimulation in vivo. Response to three light stimuli is shown. Traces are expressed as (F(t) − bg(t))/bg(t). (d) Pair-wise correlation in the absence (light off, top) and presence (light on, bottom) of wide-field stimulation for the experiment displayed in (c).
