Figure 3: Focal ISs alter the slow oscillations in the opposite hemisphere. | Scientific Reports

Figure 3: Focal ISs alter the slow oscillations in the opposite hemisphere.

From: Epileptiform activity in the mouse visual cortex interferes with cortical processing in connected areas

Figure 3

(a) Traces showing activity in Hem 1 when in Hem 2 focal ISs are induced by localized application of BMI 100 μM. (b) Magnification of a single up state and a corresponding IS recorded simultaneously in the two hemispheres. (c) The mean frequency of up states is increased after BMI in Hem 2. The thin lines indicates the change in mean frequency in the same mouse before and during the BMI treatment (Cnt, 0.57 ± 0.03 vs. BMI, 0.64 ± 0.02, paired t-test, n = 8, p = 0.004). (d) The duration of up states is shortened by ISs in Hem2 (Cnt, 0.74 ± 0.04 vs. BMI, 0.64 ± 0.03, paired t-test, n = 8, P = 0.003). (e) Distributions of lag times between the middle point of up states in Hem 1 and the onsets of IS events (dashed lines: single animals; continuous line: average). The double peak in the distribution shows that the ISs follow the up states with a small jitter evidenced by the small dispersion of the first left peak. The broader peak on the right is due to the reappearance of the up state that follows the IS with a more variable duration, as evidenced by the broader distribution. Notice that ISs are never over imposed to up states.

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