Figure 2: Neuropsychological alterations in ADA-SCID patients treated with ERT. | Scientific Reports

Figure 2: Neuropsychological alterations in ADA-SCID patients treated with ERT.

From: Alterations in the brain adenosine metabolism cause behavioral and neurological impairment in ADA-deficient mice and patients

Figure 2

PEG-ADA treated patients were divided into two groups of patients aged either less or more than 3 years of age. (a) Mental development index (MDI) as assessed by the Bayley Scale of Infant Development (2nd Edition) in young ERT treated patients (n = 7); dotted line represents the population average, shaded areas represent −1SD/−2SD respectively. (b) Total intelligence quotient (IQ), derived from verbal and performance scores, as assessed in ERT treated patients aged more than 3 years (n = 7, mean ERT treatment: 12 years); dotted line represents the population average, shaded areas represent −1SD/−2SD respectively. One Patient, marked as triangle, was assessed as total IQ score only. (c) Development of total IQ score in 4 long-term ERT treated patients over time. Last shown timepoint for each patient corresponds to total IQ represented in panel b.

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