Figure 1: Activity of temocillin and comparators against CF isolates of P. aeruginosa. | Scientific Reports

Figure 1: Activity of temocillin and comparators against CF isolates of P. aeruginosa.

From: Mechanisms of intrinsic resistance and acquired susceptibility of Pseudomonas aeruginosa isolated from cystic fibrosis patients to temocillin, a revived antibiotic

Figure 1

Panel (a): Cumulative MIC distribution for temocillin (TMO) compared to ticarcillin (TIC), with indication of MIC50, MIC90 and percentage of susceptibility according to the interpretive criteria of EUCAST (S, susceptible; R, resistant) for ticarcillin (S ≤ 16 mg/L; R > 16 mg/L); piperacillin (PIP, S ≤ 16 mg/L; R > 16 mg/L); piperacillin-tazobactam (TZP, S ≤ 16 mg/L; R > 16 mg/L); ceftazidime (CAZ, S ≤ 8 mg/L; R > 8 mg/L); imipenem (IPM, S ≤ 4 mg/L; R > 8 mg/L); meropenem (MEM, S ≤ 2 mg/L; R > 8 mg/L). A value of 16 mg/L (dotted line in the graph; EUCAST susceptibility breakpoint of ticarcillin) has been considered as cut-off value for temocillin (TMO), for comparison purposes. Panels (b–e): cross-resistance between TMO and other β-lactams. Correlation between MICs of TMO (abscissa) and TIC, CAZ, TZP or MEM (ordinate) for each individual isolate in the collection using quantile density contour analysis (JMP® version 12.1.0). The intensity of each zone (from warm to cold colours) is indicative of the proportion of isolates (from large to small) with MICs at the corresponding coordinates. The broken lines point to the MIC value above which the isolates are considered resistant for TIC, CAZ, TZP and intermediate for MEM according to EUCAST interpretive criteria. A value of 16 mg/L has been considered for TMO. The percentage of isolates is indicated in each quadrant of the figures. MICs values are expressed as the log2 of their value.

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