Figure 6: Ablation of TRIP-Br2 ameliorates the thermogenesis attenuated by ER stress in brown adipocytes. | Scientific Reports

Figure 6: Ablation of TRIP-Br2 ameliorates the thermogenesis attenuated by ER stress in brown adipocytes.

From: Transcription regulator TRIP-Br2 mediates ER stress-induced brown adipocytes dysfunction

Figure 6

(a) mRNA expression (b) protein expression of UCP1 in WT1 differentiated adipocyte treated with vehicle or tunicamycin (1 μg/ml) for 6 or 24 h (n = 3). Uncut blots are included in the Supplementary information. mRNA expression of Adrb3 (c), Aox (d), Cox8b (e), Ndufs1 (f), Sdhb (g) and Uqcrc1 (h) in differentiated WT1 adipocytes treated with vehicle or tunicamycin (1 μg/ml) for 6 or 24 h (n = 3). (i) mRNA expression of thermogenesis, fatty acid oxidation, and oxidative metabolism markers in differentiated brown adipocytes expressing Ctrl or TRIP-Br2 (n = 3). All qPCR data are normalized with TBP and presented as mean ± SEM. *p < 0.05; **p < 0.01; ***p < 0.001 (vs WT-Ctrl); #p < 0.05; ##p < 0.01; ###p < 0.001 (vs WT-Tuni).

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