Figure 5: Schematic diagram of the mechanism whereby circRNA_000203 increases cardiac fibrosis. | Scientific Reports

Figure 5: Schematic diagram of the mechanism whereby circRNA_000203 increases cardiac fibrosis.

From: CircRNA_000203 enhances the expression of fibrosis-associated genes by derepressing targets of miR-26b-5p, Col1a2 and CTGF, in cardiac fibroblasts

Figure 5

The binding interaction between circRNA_000203 and miR-26b derepresses the inhibitory effect of miR-26b on Col1a2 and CTGF in cardiac fibroblasts, resulting in the upregulation of Col1a2 and CTGF, and contributing to the enhancement of cardiac fibrosis.

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